Peter Dinklage

Winston Gooze / The Toxic Avenger / Toxie (Voice)

Jacob Tremblay

Wade

Kevin Bacon

Bob Garbinger

Elijah Wood

Fritz Garbinger

Taylour Paige

J.J. Doherty

Julia Davis

Kissy Sturnevan

Sarah Niles

Mayor Togar

Macon Blair

Dennis

Lloyd Kaufman

Spencer Wilding

Monster Garbinger

Jonny Coyne

Thad Barkabus

Atanas Srebrev

Chief Wormer

Lee Eddy

CJ Doons

Rebecca O'Mara

Shelly Gooze

David Yow

Guthrie Stockins

Chris Sharp

C.S. Hawley

Brent Werzner

Toxie Witness

Randy E. Aguebor

Coach Stanwyck

Ev Lunning

Rick Feet

Jane Levy

Cheerful Insurance Rep (voice)

Luisa Guerreiro

Toxic Avenger/Toxie